All the available evidence we have so far indicates that estriol is the safest estrogen to use to control menopausal symptoms, and that it may even be protective against breast cancer. If you need to supplement some estrogen, you can use a natural estriol.
Two pumps on hand or finger to be applied vaginally. 2 pumps = 1/8 teaspoon = .625 ml = 1 mg Estriol USP. Use the least amount possible to control symptoms. Use in conjunction with a natural progesterone creme. Not recommended during pregnancy or lactation.