This unique formula contains CardioAid® – a potent merger of the plant sterols Beta-Sitosterol, Campesterol, and Stigmasterol. The FDA recently announced that daily consumption of foods and supplements containing 800 mg of plant sterols, in combination with a diet low in saturated fat and cholesterol, can help lower cholesterol.* One serving of Summit's Beta-Sitosterol Plant Sterols contains 800 mg.
High cholesterol: Studies show that a 14-27% of LDL cholesterol and 22-30% of triglycerides levels were reduced when guggul was given to men and women with high cholesterol for 12 weeks with no change in diet or exercise. Several clinical studies were published in the Indian Journal of Medicine (volume 84) in 1986, Indian Pharmacoepia and in the Journal of the Association of Physicians in India (vol. 34 & 37) all stating the efficacy of guggul in lowering LDL cholesterol and triglycerides. Dr. David Moore and his team at the Baylor College of Medicine in Houston found that the guggulsterone, the active ingredient in the Guggul extract, blocks the activity of a receptor in the liver's cells called Farnesoid X Receptor (FXR). Later, Dr. David Mangelsdorf at University of Texas Southwestern Medical Center in Dallas confirmed that the guggul blocked the receptor and affected how cholesterol is metabolized.
Atherosclerosis: Two compounds, Z-guggulsterone and E-guggulsterone, appear to be responsible for guggul lipid's cholesterol-lowering effects. Guggul also appears to boost levels of "good" cholesterol although the exact mechanism is unknown. Both of these actions help prevent Atherosclerosis. Guggul is also an antioxidant, which helps stop the oxidization of cholesterol and the subsequent hardening of the arteries.
Niacin has long been a popular supplement for cardiovascular health, but unfortunately it can sometimes have some unpleasant side effects. The most common is a flushing of the face that occurs approximately twenty minutes after use. This is due to histamine release from the mast cells as a response to the large amounts of niacin introduced into the system at once. Due to these side effects, many people discontinue niacin use before reaching therapeutic levels. Sustained release niacin is a possible alternative, but it may cause liver enzyme elevation with very high doses. No-Flush niacin, or inositol hexanicotinate, is not a sustained release niacin but rather a form of niacin that takes longer to metabolize in the system, and thus does not trigger such an intense histamine release. Inositol hexanicotinate takes nearly ten hours to reach full serum levels in the blood, and provides all of the benefits of traditional niacin.
Policosanol, a mixture of nine high primary aliphatic alcohols, is a derivative of sugar cane wax. Octacosanol, the main component in policosanol, works as a powerful antioxidant to help maintain healthy arteries. Healthy vasculature helps support heart health. In addition to octacosanol, policosanol is made up of eight other aliphatic alcohols that are also helpful in promoting cardiovascular health.